MYOCD, myocardin, 93649

N. diseases: 79; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression group BEFREE We show here by array-based comparative genomic hybridization, fluorescence in situ hybridization, and expression analysis approaches that MYOCD gene is highly amplified and overexpressed in human retroperitoneal leiomyosarcomas (LMS), a very aggressive well-differentiated tumor. 19276386 2009
CUI: C0023269
Disease: leiomyosarcoma
leiomyosarcoma 		0.030 AlteredExpression disease BEFREE We show here by array-based comparative genomic hybridization, fluorescence in situ hybridization, and expression analysis approaches that MYOCD gene is highly amplified and overexpressed in human retroperitoneal leiomyosarcomas (LMS), a very aggressive well-differentiated tumor. 19276386 2009
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.020 Biomarker group BEFREE We report that myocardin, a powerful myogenic transcriptional coactivator, negatively regulates VSMC inflammatory activation and vascular disease. 25614278 2015
CUI: C1449563
Disease: Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Familial Idiopathic 		0.020 AlteredExpression disease BEFREE We observed an increase in MYOCD levels in the endomyocardial biopsies of DCM patients associated with renal failure compared to DCM alone. 30971740 2019
CUI: C0152021
Disease: Congenital heart disease
Congenital heart disease 		0.310 GeneticVariation group BEFREE We identified a rare human sequence variation in MYOCD in a patient with congenital heart disease that resulted in a missense mutation at codon 259 (K259R). 18852265 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.040 Biomarker group BEFREE We here hypothesized that Rho kinase (ROCK) acts as a novel mediator that regulates intrinsic VSMC mechanical properties through the serum response factor (SRF) /myocardin pathway and consequently regulates aortic stiffness and blood pressure in hypertension. 29169155 2017
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.020 Biomarker phenotype BEFREE We here hypothesized that Rho kinase (ROCK) acts as a novel mediator that regulates intrinsic VSMC mechanical properties through the serum response factor (SRF) /myocardin pathway and consequently regulates aortic stiffness and blood pressure in hypertension. 29169155 2017
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.020 AlteredExpression disease BEFREE We also conducted realtime PCR and Western blot analysis to study the mRNA and protein expression level of MYOCD between different groups (intracranial aneurysm vs. normal control) or cells treated with scramble control, miR-9 mimics, MYOCD siRNA, and miR-9 inhibitors, indicating the negative regulatory relationship between miR-9 and MYOCD. 27824808 2016
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.020 Biomarker group BEFREE Urokinase receptor associates with myocardin to control vascular smooth muscle cells phenotype in vascular disease. 22075245 2012
CUI: C0042345
Disease: Varicosity
Varicosity 		0.010 Biomarker disease BEFREE Together, these results demonstrated that IQGAP1 may regulate the phenotypic switch of VSMCs by myocardin pathway, which is critical for the pathological progression of varicose vein. 25400725 2014
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE Thus, these data reveal the new insight that myocardin meditates apoptosis in breast cancer through affecting maspin re-expression and epigenetic modification to regulate the development of breast cancer, thereby raising the possibility of its use in breast cancer therapy. 24607789 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Thus, these data reveal the new insight that myocardin meditates apoptosis in breast cancer through affecting maspin re-expression and epigenetic modification to regulate the development of breast cancer, thereby raising the possibility of its use in breast cancer therapy. 24607789 2014
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.010 AlteredExpression disease BEFREE Thus, targeting LPA-LPA<sub>1</sub> signaling and/or myocardin-related transcription factor/serum response factor-induced transcription could be promising therapeutic strategies for renal fibrosis. 27927603 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 AlteredExpression disease BEFREE Thus, SRF-MYOCD overexpression in small cerebral arteries appears to initiate independently of Abeta a pathogenic pathway mediating arterial hypercontractility and CBF dysregulation, which are associated with Alzheimer's dementia. 17215356 2007
CUI: C0007194
Disease: Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 		0.010 GeneticVariation disease BEFREE Thus, a myocardin promoter allelic variant existing in the normal Cretan population was associated with decreased left ventricular mass in HCM patients and decreased myocardin mRNA levels in peripheral blood. 18028454 2008
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.020 Biomarker disease BEFREE This study presents guidelines for the prediction and validation of the IA regulator MYOCD in competitive endogenous RNA networks and facilitates the development of novel therapeutic and diagnostic tools for IAs. 25868147 2015
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.010 AlteredExpression disease BEFREE This study demonstrates that myocardin is involved in the activation of HSC; myocardin may serve as a novel therapeutic target in the treatment of liver fibrosis. 19793196 2010
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		0.010 GeneticVariation disease BEFREE This study aimed to investigate the associations between response to methadone maintenance treatment (MMT) and polymorphisms in genes coding for the OPRM1 opioid receptor, the metabotropic glutamate receptors GRM6 and GRM8, the nuclear receptor NR4A2, the photolyase enzyme cryptochrome 1 (CRY1), and the transcription factor myocardin (MYOCD), which have previously been associated with the risk of opioid dependence disorder. 20560679 2010
CUI: C0549253
Disease: Dilatation of the bladder
Dilatation of the bladder 		0.300 Biomarker phenotype GENOMICS_ENGLAND These results were supported by cosegregation of MYOCD variants with the phenotype in 4 unrelated families by in vitro transactivation studies in which pathogenic variants resulted in abrogated SM gene expression and by the finding of megabladder in 2 distinct mouse models with reduced Myocd activity. 31513549 2019
CUI: C0549253
Disease: Dilatation of the bladder
Dilatation of the bladder 		0.300 Biomarker phenotype GENOMICS_ENGLAND These results were supported by cosegregation of MYOCD variants with the phenotype in 4 unrelated families by in vitro transactivation studies in which pathogenic variants resulted in abrogated SM gene expression and by the finding of megabladder in 2 distinct mouse models with reduced Myocd activity. 31513549 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.040 Biomarker group BEFREE These observations suggest that altered glucose metabolism and G6PD overactivation play a key role in switching the PASM cells from the contractile to synthetic phenotype by increasing Sp1 and HIF-1α, which suppresses myocardin, a key cofactor that maintains smooth muscle cell in contractile state, and increasing hypoxia-induced PASM cell growth, and hence contribute to pulmonary arterial remodeling and pathogenesis of pulmonary hypertension. 25480333 2015
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 Biomarker disease BEFREE These data demonstrate that miR-145 modulates the phenotypic switch of VSMCs from a contractile to a proliferative state via KLF5 and MYOCD in atherosclerosis. 26992033 2016
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE These data demonstrate that miR-145 modulates the phenotypic switch of VSMCs from a contractile to a proliferative state via KLF5 and MYOCD in atherosclerosis. 26992033 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 Biomarker disease BEFREE Therefore, we hypothesized that <i>myocardin</i> is expressed in MCs and that high glucose is involved in the regulation of myocardin and downstream contractile genes in the context of DN. 29152089 2017
CUI: C0002793
Disease: Anaplasia
Anaplasia 		0.010 GeneticVariation disease BEFREE The inhibitory effects of DNA demethylation on global 5-methylcytosine content and ten-eleven translocation 2 hypermethylation in atherosclerotic aorta can recover 5-hydroxymethylcytosine enrichment at the Myocardin promoter and prevent VSMC dedifferentiation and vascular remodeling. 27879253 2017